Intel-based Mac Computer: Macintosh OS X 10.10 or higher USB type-A port Internet access; Infrared (IR): The Harmony 665 controls your devices using infrared (IR) light meaning that there must be a direct line of sight between the Harmony remote and your component's IR eye or external IR receiver. The remote has an IR transmission range of up. Installing and using Logitech Harmony Remote Software for macOS 10.15 will prompt a Keystroke Receiving message from your mac. It will ask for you to grant access for our application. It is not necessary to grant access. Harmony Remote Software uses the JavaFX engine, and one of the features of the engine is to receive keystrokes. Oct 30, 2015 Hey guys I have a problem with the MyHarmony software i wanted to change a little setting on my 650 remote but when i try to start the software it gets stuck on the loading screen at 50%. I did reinstall the software but it still doesn't work. I did a google search and i found on the logitech. Over the last few weeks, we have made solid progress toward Harmony software compatibility for Harmony 900, 1000 and 1100 customers who use 64-bit Mac OS X. The engineering team is qualifying the latest version of 64-bit Harmony Remote Client for OS Snow Leopard (10.6.8) and OS Lion (10.7). Jan 08, 2018 Verify now that the dongle's Bluetooth transmitter is the one that is connecting your device, and not the Mac's built-in Bluetooth. OPTION-click on the Bluetooth icon in the Menu Bar; a menu drops down; on line 3 you will see 'Address' followed by the number-letter sequence of the currently operating Bluetooth transmitter.
According their site, the mouse works with 'Bluetooth Smart Ready device'.
http://www.logitech.com/en-us/product/mx-anywhere2 ( Check System Requirements in TECHNICAL SPECIFICATIONS section )
Logitech Harmony One Software Mac Os X
Bluetooth Smart Ready on Mac means Bluetooth 4.0 hardware with Yosemite or later.
Unfortunately BT on your Macbook Pro (mid 2010) is BT2.1+EDR
( If you want to be sure, Logitech provides a procedure to check the PC/Mac is Bluetooth Smart Ready or not )
Logitech Harmony Software Windows 10
I guess your only option is use of USB hub if you don't have available USB port,